国际中医药转化医学研究所
张容容
发布时间:2020-07-10      来源:       点击:

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张容容

女,博士,副研究员,硕士生导师,研究领域主要为中药药效物质发现及药理机制研究,采用中药“药效-物质-靶点-分子机制”研究模式,揭示中药药效物质、靶点及分子机制。现兼任广东省中药学会中药饮片专业委员会委员,广东省保健协会脑健康分会常务委员,广东省药理学会中药药理专业委员会委员。主讲《中药化学》与《天然药物化学》理论和实验课程。近年来发表SCI收录论文20余篇,授权发明专利3项。

教育、工作经历

2017-04 至今,金沙2004路线js5,金沙2004路线js5,副研究员
2012-09 至 2016-12,暨南大学,中药学,博士
2015-10 至 2016-10,英国兰卡斯特大学,化学生物学,联合培养博士
2010-09 至 2012-06,暨南大学,制药工程,硕士
2005-09 至 2009-06,山西中医学院,中药学,学士

研究方向

1)中药化学;2)中药药理学

承担课程

《中药化学》、《天然药物化学》

科研及教学课题

1. 广东省教育厅,特色创新项目(自然科学),2022KTSCX027,民族药断节参中C21甾苷特异性靶向肿瘤P-gp逆转多西他赛耐药的“构-效”关系及分子机制研究,2023-01 至 2024-12,5万元,在研,主持
2. 广东省科技厅,广东省自然科学基金-面上项目,2022A1515011212,岭南中药三叉苦抑制NLRP3炎性小体/caspase-1轴治疗阿尔兹海默症的药效物质基础及分子机制,2022-01 至 2024-12,10万元,在研,主持
3. 国家自然科学基金青年科学基金项目,81703814,断节参中C21甾苷类成分的分离鉴定及其肿瘤耐药逆转活性研究,2018/01-2020/12,20万元,主持,在研。
4. 广州市科技计划项目一般科学研究,2018-1002-SF-0474,八角瓜乳汁中强心苷类成分的分离鉴定及其强心作用机制研究,2018/04-2021/03,20万元,主持,在研。
5. 金沙2004路线js52017年度“高水平大学建设”“杏林后备人才”项目, A1-AFD018171Z0317,A1-AFD018161Z0140, 2017/04-2020/03,50万元,在研,主持。

代表性论文论著

1.Zhang J, Guo XJ, Chen XJ, Zhang RR, Ma BP, Liu ZQ. Ent-atisane diterpenoids from Euphorbia wallichii and their anti-influenza A virus activity. Phytochemistry. 2024 Feb 3;220:113996.
2.Ding XY, Wen JR, Lin WY, Huang GY, Feng Q, Duan L, Zhang SJ, Liu Z, Zhang RR, Wang Y. Phloroglucinol derivatives, coumarins and an alkaloid from the roots of Evodia lepta Merr. Phytochemistry. 2023 Sep;213:113774.
3.Zhang F, Wang Y, Yue J, Zhang RR, Hu YE, Huang R, Ji AJ, Hess BA Jr, Liu Z, Duan L, Wu R. Discovering a uniform functional trade-off of the CBC-type 2,3-oxidosqualene cyclases and deciphering its chemical logic. Sci Adv. 2023 Jun 9;9(23):eadh1418.
4.Ji Z, Fan B, Chen Y, Yue J, Chen J, Zhang RR, Tong Y, Liu Z, Liang J, Duan L. Functional characterization of triterpene synthases in Cibotium barometz. Synth Syst Biotechnol. 2023 Jun 25;8(3):437-444. 
5.Xiao X, Zhang X, Yang Z, Ji A, Wang C, Feng Q, Liu Z, Zhang RR. Six Unusual Meroterpenoids from the Leaves of Psidium guajava L. and Their PTP1B Inhibitory Activities. J Agric Food Chem. 2022 Apr 6;70(13):4000-4006.
6.Ji AJ, Ma Q, Kong MY, Li LY, Chen XL, Liu ZQ, Wu JJ, Zhang RR. Two cardenolide glycosides from the seed fairs of Asclepias curassavica and their cytotoxic activities. Chin J Nat Med. 2022 Mar;20(3):202-209.
7.Zhang L, Yuefang L, Min H, Wenbo C, Duan L, Liu Z, Lu L, Zhang RR. Six C21 steroidal glycosides from Cynanchum wallichii Wight roots and their multidrug resistance reversal activities. Phytochemistry. 2022 Jul;199:113172.
8.Huang L, Hu Y, Huang R, Chen J, Zhang X, Yue J, Feng L, She Y, Ji A, Zheng Y, Liu Z, Zhang RR, Duan L. Oxidosqualene Cyclases Involved in the Biosynthesis of Diverse Triterpenes in Camellia sasanqua. J Agric Food Chem. 2022 Jul 6;70(26):8075-8084.
9.Huang GY, Cui H, Lu XY, Zhang LD, Ding XY, Wu JJ, Duan LX, Zhang SJ, Liu Z, Zhang RR. (+/-)-Dievodialetins A-G: Seven pairs of enantiomeric coumarin dimers with anti-acetylcholinesterase activity from the roots of Evodia lepta Merr. Phytochemistry. 2021 Feb;182:112597.
10.Zhang RR, Chen Z, Zhang L, Yao W, Xu Z, Liao B, Mi Y, Gao H, Jiang C, Duan L, Ji A. Genomic Characterization of WRKY Transcription Factors Related to Andrographolide Biosynthesis in Andrographis paniculata. Front Genet. 2021 Jan 18;11:601689.
11.Zhang RR, Hu RD, Lu XY, Ding XY, Huang GY, Duan LX, Zhang SJ. Polyphenols from the flower of Hibiscus syriacus Linn ameliorate neuroinflammation in LPS-treated SH-SY5Y cell. Biomed Pharmacother. 2020 Oct;130:110517.
12.Zhang RR, Lin ZX, Lu XY, Xia X, Jiang RW, Chen QB. CGY-1, a biflavonoid isolated from cardiocrinum giganteum seeds, improves memory deficits by modulating the cholinergic system in scopolamine-treated mice. Biomed Pharmacother. 2019 Mar;111:496-502.

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