药物化学学部
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尹利娜
发布时间:2022-03-18      来源:       点击:


尹利娜

学位:博士

职称:教授

教育工作经历

2017/11至今    金沙2004路线js5  金沙2004路线js5  教授

2012/1-2015/4   Elexopharm制药公司  科研助理

2006/5-2011/6   德国萨尔大学  药物化学博士  导师:Rolf W. Hartmann

2001/9-2004/7   沈阳药科大学  药物化学硕士  导师:赵临襄

1996/9-2000/7   沈阳药科大学  化学制药学士

研究方向

1)基于中药活性分子的选择性甾体合成酶抑制剂的研究

2)细菌群体感应PQSR抑制剂的研究

科研及教学课题

1. 广东省新药创制重大专项子项目,2019B02021002,小分子创新药物的研究与开发,2018/1-2022/6,40万元,在研,主持。

2. 金沙2004路线js5杏林青年学者,2017/11-2020/10,100万元,主持。

承担课程

  • 主要承担《药物化学》、《药物设计学》、《药物合成学》、《药学英语》等课程。

发表论文

1 Yin, L.; Hu, Q.; Emmerich, J.; Lo, M. M.; Metzger, E.; Ali, A.; Hartmann, R. W. Novel pyridyl- or isoquinolinyl- substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J. Med. Chem. 2014, 57, 5179–5189.

2 Yin, L.; Hu, Q.* CYP17 inhibitors — abiraterone, C17,20-lyase inhibitors and multi-targeting agents. Nat. Rev. Urol. 2014, 11, 32-42.

3 Yin, L.; Hu, Q.* Chimera induced protein degradation: PROTACs and beyond. Euro. J. Med. Chem. 2020, 206, 112494

4 Zhu, H.; Liu, M.; Li, H.; Guan, T.; Zhang, Q.; Chen, Y.; Liu, Y.; Hartmann, R. R.; Yin, L.;*  Hu, Q.* Design, synthesis and biological evaluation of pyridyl substituted benzoxazepinones as potent and selective inhibitors of aldosterone synthase. Chin. Chem. Lett. 2021, 32, 2327-2332.

5 Yin, L.;* Xue, Y.; Shang, Q.; Zhu, H.; Liu, M.; Liu, Y.; Hu, Q.* Pharmaceutical inhibition of neddylation as promising treatments for various cancers. Curr. Top. Med. Chem. 2019, 19, 1059-1069.

6 Yin, L.; Hu, Q.; Hartmann, R. W. Tetrahydropyrroloquinolinone type dual inhibitors of aromatase / aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks. J. Med. Chem. 2013, 56, 460–470.

7 Yin, L.; Lucas, S.; Maurer, F.; Kazmaier, U.; Hu, Q.;* Hartmann, R. W.* Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydro-pyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing’s syndrome. J. Med. Chem. 2012, 55, 6629–6633.

8 Yin, L.; Hu, Q.* Drug discovery for breast cancer and coinstantaneous cardiovascular disease: What is the future? Future Med. Chem. 2013, 5, 359–362.

9 Ma, L.; Yin, L.;* Hu, Q.* Therapeutic compounds for Cushing's syndrome: a patent review (2012-2016). Expert Opin. Ther. Pat. 2016, 26, 1307–1323.

10 Hu, Q.; Yin, L.; Ali, A.; Cooke, A. J.; Bennett, J.; Ratcliffe, P.; Lo, M. M.; Metzger, E.; Hoyt, S.; Hartmann, R. W. Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability. J. Med. Chem. 2015, 58, 2530–2537.

11 Hu, Q.; Yin, L.; Hartmann, R. W. Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases. J. Med. Chem. 2014, 57, 5011–5022.

12 Hu, Q.; Yin, L.; Hartmann, R. W.* Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer. J. Med. Chem. 2012, 55, 7080–7089.

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